Macrocytic anemia: peripheral blood smear to differentiate megaloblastic anemia from nonmegaloblastic anemia.
Microcytic anemia: iron panel to evaluate for iron deficiency anemia further evaluation depends on iron panel findings.
Order initial tests to evaluate the underlying cause of anemia.
Based on MCV, classify into microcytic, macrocytic, and normocytic anemia.
If acute blood loss anemia is suspected → see acute blood loss anemia.
Check CBC to confirm anemia and assess severity.
The causes of microcytic anemia can be remembered with IRON LAST: IRON deficiency, Lead poisoning, Anemia of chronic disease, Sideroblastic anemia, Thalassemia.
Nonmegaloblastic anemia: normal DNA synthesis without hypersegmented neutrophilsīoth iron deficiency anemia and anemia of chronic disease can manifest with normocytic anemia in the initial phase and microcytic anemia later on.īone marrow failure (e.g., due to myeloproliferative malignancy, myelodysplastic syndrome) can manifest with microcytic, normocytic, or macrocytic anemia.
Megaloblastic anemia: impaired DNA synthesis and/or repair with hypersegmented neutrophils.
Anemia of chronic disease (early phase).
Iron deficiency anemia (the most common).
Insufficient nucleus maturation relative to cytoplasm expansion due to.
Decreased blood volume and/or d ecreased erythropoiesis.
0 kommentar(er)
